Princess Margaret Cancer Consortium

The Princess Margaret Cancer Consortium (PM2C) coalesces the expertise and efforts of clinicians, pathologists, data and translational scientists, bioinformaticians as well as software developers to contribute retrospectively and prospectively assembled patient cohorts and guide data interpretation in the relevant clinical and molecular context.

Currently, the PM2C consists of a partnership between the Princess Margaret Cancer Centre – University Health Network (PM-UHN), and the Ontario Institute for Cancer Research (OICR). PM-UHN and OICR will collaborate to deliver on specific requirements for genomic and transcriptomic data generation and federation for the MOHCCN. Through this partnership, UHN-PM and OICR will establish models for governance and decision-making. PM-UHN will lead the PM2C for MOHCCN by leveraging and building upon many of its existent infrastructure and specific capabilities including clinical research supports, pathology and biobank resources, translational research capabilities, data science and sharing, patient and community outreach activities. The vision of this consortium is to act as one of potentially several hubs in Ontario to serve as primary entry points of clinical and molecular data into the MOHCCN.

PM2C is led by Dr. Lillian Siu and supported by its Steering Committee, which consists of Dr. Lillian Siu, Dr. Aaron Schimmer, Dr. Trevor Pugh, and Dr. Bradly Wouters.

For the first two years of its inception, the PM2C will contribute patient data derived from 18 projects including solid, blood and rare cancers.  PM2C is actively planning to add member sites across Ontario to increase its footprint of precision cancer medicine initiatives.

 

Partners

Goals and Objectives

  1. Establish the personnel and infrastructure to develop the PM-UHN local Digital Health and Discovery Platform appliance to enable data sharing across member sites
  2. Bolster core capabilities in bioinformatics, text mining, pathological assessment, molecular profiling (Whole Genome and Transcriptome Analysis (WGTA), immunoprofiling, etc.)
  3. Recruit and link in additional Ontario centres as PM2C member sites
  4. Plan and launch outreach activities and patient engagement programs to include underserved and hard-to-reach populations
  5. Create opportunities to partner with industry such as establishing a network-wide prospective clinical trial to enroll patients with specific biomarkers or signatures
  6. Increase training opportunities for trainees such as studentships and fellowships; and engage early career investigators to participate in MOHCCN activities via career awards for early career researcher

Projects

Each year a substantial number of projects are nominated to become part of MOHCCN. Prior to their selection, cohorts are reviewed by the PM2C Steering Committee using the following eligibility criteria:

  1. Address at least one of the key questions set forth by the MOHCCN Scientific Questions Working Group
  2. Alignment with MOHCCN White Papers (Year 2+ cohorts)
  3. Willingness and ability (e.g. consent language allowance) to share data and biospecimens
  4. Availability of banked biospecimens for additional analysis
  5. Representation of patients with different cancer types or molecular groups
  6. Engagement of multi-disciplinary clinical and research groups within and/or outside PM-UHN
  7. Status of gold standard readiness (e.g. readiness of WGTA data, clinical data, etc.)
  8. Availability of matched funding support
  9. Have undergone internal and/or external scientific review

YEAR 1 PROJECTS

ProjectsProject leads
INSPIRE: Phase II study of pembrolizumab in solid tumorsSiu
OCTANE: Ontario-wide targeted sequencing in solid tumorsBedard, Siu
BioDIVA: Biomarker discovery in high grade serous ovarian cancerOza, L'heureux
IO-ALINES: Immuno-Oncology treatment and adenocarcinoma of lung in never smokersTsao, Liu
PALMS: Patient-derived lung cancer modelsTsao, Liu
COMPASS: Molecular characterization of advanced PDAC for treatment selection
BIO-CAN: Biomarkers in oral head and neck cancerBratman et al.

YEAR 2 PROJECTS

ProjectsProject leads
IRIS: Pan-cancer acquired versus primary immune resistance in solid tumorsSiu, Spreafico
OCTANE Non-Actionable: Non actionable mutations in targeted sequencing in solid tumorsBedard, Siu
SAMBA: Molecular residual disease in high risk melanomaSpreafico
ctDNA in HCC: Non-invasive monitoring post surgery or transplant in hepatocellular carcinomaPugh, Sapisochin, Ghanekar
GOLDEN: Immuno-oncology agents in the treatment of advanced renal cell carcinomaHansen
PALM-X: Xenografted vs not-xenografted cases in non-small cell lung cancerTsao, Liu
CHARM: Circulating tumor DNA in hereditary and high risk malignanciesPugh, Kim
READILY: Profiling for newly diagnosed lymphomaKridel
BTC – CYPRESS & Retro-B: Profiling for cholangiocancer and gallbladder cancerGallinger, Knox
PASS-01: Randomized trial of mFFX (modified FOLFIRINOX: 5-fluorouracil, leucovorin, oxaliplatin and irinotectan) and GA (gemcitabine + nanoparticle albumin-bound (nab)-paclitaxel)  in first-line treatment of advanced pancreatic cancerKnox
CPC-G: Long-term follow up for intermediate risk prostate cancerHe, Berlin, Fleshner, van der Kwast