Evaluating genomic landscape of pancreatic cancer and comparing to clinical outcome

Project aims/goals

The overall goals of this project is to perform a genomic landscape characterization of resected pancreas

cancer, relationships to outcome, with two main aims:

AIM 1. Genomic Profiling: Perform comprehensive genomic profiling of pancreatic cancer tumors from our cohort of patients in order to identify DNA mutations, copy number variations, gene expression patterns.
AIM 2. Perform a Correlation Analysis of the identified genetic alterations with clinical outcomes, to determine if specific mutations, alterations, or patterns are associated with better or worse responses to treatment, disease progression, or survival rates and time to relapse.

Evaluating the genomic landscape of pancreatic cancer and correlating it with clinical outcomes is

essential for advancing our understanding of the disease, optimizing treatment strategies, and ultimately

improving the prognosis and quality of life for patients with this challenging form of cancer. We have

biobanked pancreas cancers from over 50 patients, who are followed clinically at the JGH hospital. In this

project, we will define the genomic landscape of these resectable tumors, and try to determine factors

that can be related to time to relapse (at all, early, and late).