Project Title: The Legresley Biliary Registry and Comprehensive Profiling of Young Patients with Biliary Tract Cancers or those with Underlying Inflammatory Disorders (BTC-CYPRESS)
Project Duration: 2021-2026
MOHCCN Consortium: Princess Margaret Cancer Consortium
Investigators: Dr. Steven Gallinger, Dr. Jennifer Knox, Dr. Faiyaz Notta
of BTC tumorigenesis.
Biliary tract cancers (BTC) comprise a heterogeneous group of malignancies, which include gallbladder cancer (GBC) and cholangiocarcinomas (CCA). Molecular profiling of tumours has identified a number of potential targets in BTC underscoring the need to reclassify this group of malignancies. This cohort is a prospective study where epidemiological data, blood, tumour and stool samples will be collected from patients diagnosed with advanced BTC. A sub-cohort who are aged 55 years or younger or have underlying inflammatory disorders will be enrolled and compared to patients with typical BTC.