The Legresley Biliary Registry and Comprehensive Profiling of Young Patients with Biliary Tract Cancers or those with Underlying Inflammatory Disorders (BTC-CYPRESS)
Project Title: The Legresley Biliary Registry and Comprehensive Profiling of Young Patients with Biliary Tract Cancers or those with Underlying Inflammatory Disorders (BTC-CYPRESS)
Project Duration: 2021-2026
MOHCCN Consortium: Princess Margaret Cancer Consortium
Investigators: Dr. Steven Gallinger, Dr. Jennifer Knox, Dr. Faiyaz Notta
Partners:
- Princess Margaret Cancer Centre
- OICR
Aim/goals:
- To investigate the genetic information (WGS/RNAseq) found in patients diagnosed with advanced biliary tract cancer (BTC) with the hopes of finding ways to better treat and improve survival among patients with BTC.
- To establish a repository of samples and data including blood, stool, fresh/archival tumour tissue and comprehensive, prospectively collected clinical data.
- To prospectively determine the demographics and potential environmental risk factors predisposing to the development of BTC through detailed questionnaires and to further evaluate how risk factors may impact outcomes.
- To evaluate the prevalence of germline alterations that may contribute to the development
of BTC tumorigenesis.
Summary:
Biliary tract cancers (BTC) comprise a heterogeneous group of malignancies, which include gallbladder cancer (GBC) and cholangiocarcinomas (CCA). Molecular profiling of tumours has identified a number of potential targets in BTC underscoring the need to reclassify this group of malignancies. This cohort is a prospective study where epidemiological data, blood, tumour and stool samples will be collected from patients diagnosed with advanced BTC. A sub-cohort who are aged 55 years or younger or have underlying inflammatory disorders will be enrolled and compared to patients with typical BTC.