Project Title: The Canadian Prostate Cancer Genome Project (CPC-GENE)
Project Duration: 2011-2025
MOHCCN Consortium: Princess Margaret Cancer Consortium
Investigators: Dr. Hansen He, Dr. Alejandro Berlin, Dr. Theodorus van der Kwast, Dr. Neil Fleshner
Partners:
Canadian prostate cancer genome network (CPC-G) is a cohort of 450 intermediate-risk prostate cancer with long-term clinical follow-up (median = 10.2 years). We have performed multimodal genomic and epigenomic profiling of these 450 prospectively-accrued fresh-frozen tissue specimens, including whole-genome sequencing, EPIC 850K DNA methylation arrays, ultra-deep (~200M reads/sample) RNA-sequencing, multi-color immunohistochemistry, proteomics, and cell free-DNA methylation. We also explore how germline and somatic mutations affects tumor microenvironment and tumor progression. This cohort is included in ICGC PRAD-CA and Pan Prostate Cancer Group (PPCG), providing further integration into clinically-driven cancer genomics initiatives from around the world.